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KMID : 0043320110340101615
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Archives of Pharmacal Research
2011 Volume.34 No. 10 p.1615 ~ p.1621
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Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents
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Taher Azza T.
Khalil Nadia A.
Ahmed Eman M.
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Abstract
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A series of new isatin-thiazoline 3a?h and isatin-benzimidazole 4a?h derivatives were synthesized via condensation of isatin Mannich bases 2a?h with either 2-aminothiazoline or 2-aminobenzimidazole. The structures of the newly synthesized compounds were characterized by spectral data. The anti-breast cancer activity of some of the synthesized compounds was assessed in the MCF-7 human breast cancer cell line. The results showed that compounds 4b, 4d and 4g possess significant antiproliferative activity against MCF-7 cells.
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KEYWORD
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Isatin, Benzimidazole, Thiazoline, Breast cancer, Anticancer activity
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